Analysis of syndrome of inappropriate anti-diuresis and cerebral salt wasting in patients with acute stroke
Department of General Medicine, BGS institute, Bangalore, Karnataka, India.
Research Article
International Journal of Frontiers in Medicine and Surgery Research, 2023, 03(02), 026–032.
Article DOI: 10.53294/ijfmsr.2023.3.2.0070
Publication history:
Received on 07 June 2023; revised on 26 July 2023; accepted on 29 July 2023
Abstract:
Hyponatremia in hospitalized patients can significantly alter the morbidity, mortality, especially in chronic neurological patients. Most commonly, it is attributed to SIADH, and in stroke it occurs due to AVP secretion inappropriate to the osmotic threshold. The suppressed proximal renal tubular transport in this condition can lead on to bicarbonaturia and hypouricemia. CSW, on the other hand, is essentially a volume depleted state, which occurs due to the combined effects of decreased sympathetic outflow and increased natriuretic peptides. This resultant natriuresis leads to volume depletion and an appropriate AVP response. The treatment for SIADH AND CSW varies, and the outcomes vary considerably too. Hence, we performed this study to study the clinical profile of stroke patients with hyponatremia, and to identify the factors associated with the same.
Keywords:
SIADH; CSW; Hyponatremia; Volume Depleted State; Cerebral Oedema
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0