Anti-hyperglycemic and Anti-oxidant activities of Ethanolic extract of Lantana camara Leaves

Venkatesh S 1, *, Latha R 2, Anaswara R Nath 1, Jincy T C 1, Muhammed Shibli P C 1 and Suresh A 1

1 Department of Pharmacology, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India.
2 Department of Pharmacology, J. K. K. Nattraja College of Pharmacy, Kumarapalayam, Namakkal, Tamilnadu, India.
 
Research Article
International Journal of Frontiers in Life Science Research, 2021, 01(02), 005–015.
Article DOI: 10.53294/ijflsr.2021.1.2.0043
Publication history: 
Received on 16 July 2021; revised on 27 August 2021; accepted on 29 August 2021
 
Abstract: 
The present study has been undertaken to evaluate In-vivo Anti–hyperglycemic and anti–oxidant activities of ethanolic Lantana camara leaves extract (LCE). The extract was prepared by cold percolation process. Phytochemical screening indicates that the presence of flavanoids, phenols, carbohydrates etc. The Anti-hyperglycemic activity of the extract was studied by In-vivo using Streptozotocin induced diabetes rat models. Glibenclamide was used as a standard drug to compare the blood glucose level. The groups treated with Lantana camara leaves extract at dose 200 and 400 mg/kg prevented the diabetes condition in a dose related manner. LCE and Glibenclamide treated rats showed decreased LPO that is associated with increased activity of SOD and catalase. The increase in the level of lipid peroxides in plasma generally is thought to be the consequence of increased production of and liberation in to the circulation of tissue lipid peroxides due to pathological changes. This action shows the Anti-peroxidative effect of LCE. The results obtained thus suggest that 50% ethanolic Lantana camara leaves extract possesses potent Anti-hyperglycemic and Anti-oxidant activity.
 
Keywords: 
Lantana camara; Ethanol extract; Streptozotocin; Anti-hyperglycemic activity; Anti-oxidant activity.
 
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