Anti-hypercholesterol effects of microencapsulation of leaf extract Stevia rebaudiana
STIFAR Yayasan Pharmasi, Letjend Sarwo Edie Wibowo KM 1, Semarang 50193, Indonesia.
Research Article
International Journal of Frontiers in Chemistry and Pharmacy Research, 2022, 02(01), 001–006.
Article DOI: 10.53294/ijfcpr.2022.2.1.0041
Publication history:
Received on 03 September 2022; revised on 10 October 2022; accepted on 13 October 2022
Abstract:
Several studies have proven that Stevia rebaudiana Bertoni leaf extract has been shown to be able to lower cholesterol. Furthermore, microencapsulation was developed to protect the content in the plant. This study aims to determine the effect of microencapsulated preparations of leaf extract of Stevia rebaudiana Bertoni on cholesterol in male Wistar rats. The encapsulants used are inulin and chitosan. This study was conducted with the aim of making hypercholesterol rats induced by alloxan at a dose of 150 mg/KgBW rats intraperitoneally. Hypercholesterolemic rats were given microencapsulated Stevia rebaudiana Bertoni leaf extract at different dose levels (100, 300, 700 and 1000 mg/kgBW) for 8 weeks; control mice were fed a basal diet during this period. The results of the study concluded that the microencapsulation of the leaf extract of Stevia rebaudiana Bertoni had an antihypercholesterolemic effect on male Wistar strain rats.
Keywords:
Leaf extract of Stevia rebaudiana Bertoni; Antihypercholesterolemia; Microencapsulation
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