Formulation and evaluation of ranitidine floating tablet
1 Akhil Bharti College of Pharmacy, Kharpa, Ratibad, Bhopal, Madhya Pradesh, India.
2 School of Pharmacy, LNCT University, Kolar, Bhopal, Madhya Pradesh, India.
3 Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.
Research Article
International Journal of Frontiers in Biology and Pharmacy Research, 2022, 03(01), 046–052.
Article DOI: 10.53294/ijfbpr.2022.3.1.0022
Publication history:
Received on 10 December 2021; revised on 14 January 2022; accepted on 16 January 2022
Abstract:
The aim of present investigation is to formulate floating tablet to increase duration of action of ranitidine. Floating tablet of ranitidine has long duration of action as compare to its sustained release formulation, Floating tablet has double duration of action than sustained release formulation.
Floating tablet is developed by using various polymers like HPMC (15000) and few grades of carbopol, citric acid and sodium bicarbonate were added for effervescence. Tablets were prepared by wet granulation technique by using single operation punch machine in different formulation with polymers, also included testing of some physical parameters like swelling index , hardness and weight variations.
In vitro buoyancy evaluation was carried-out and in vitro release of drug was also performed. Increase in quantity of effervescence did not affect buoyancy while facilitating the release of drug. In-Vitro drug release increased when increased quantity of polymers like HPMC and carbopol.
Keywords:
Polymers; HPMC; Citric acid; Sodium bicarbonate; Effervescence; Buoyancy
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