“DURYSTA” the first biodegradable sustained release implant for the treatment of open-angle glaucoma
Bio-Mathematical Lab 34, School of Computational and Integrative Sciences Jawaharlal Nehru University, New Delhi-110067, (India).
Research Article
International Journal of Frontiers in Biology and Pharmacy Research, 2021, 01(02), 001–007.
Article DOI: 10.53294/ijfbpr.2021.1.2.0042
Publication history:
Received on 28 August 2021; revised on 07 October 2021; accepted on 09 October 2021
Abstract:
A study for “DURYSTA” in the treatment of open angle glaucoma has been done in this work. A angle between the cornea and iris is open whereas the trabecular meshwork is partially blocked, that obstructs the outflow of aqeous humor and lead to vision loss and damage the optic nurve that is known as open angle glucoma. This model presented the study for outflow of watery clear liquid called aqueous humor from the eye through the trabacular meshwork into the Schlemm's Canal in the human eye. This circular lymphatic-like vessel which is called Canal of Schlemm is modeled as a permeable flexible canal with a trabecular meshwork that keeps it open. Aqueous humor seeps through trabacular meshwork and reaches to Schlemm's canal. The inner wall of the canal is porous and it is considered that between two collecting channels the segment of canal is assumed as a circular cross-section tube. In this model, the flow and pressure characteristics of the aqueous fluid are drawn, and the effect of the main limitations and parameters on these profiles is extracted and explained. The effects of “DURYSTA” on these parameter have also been extracted and shown.
Keywords:
DURYSTA; Circular cross-section; Open Angle Glaucoma; Aqueous Humor; Schlemm’s Canal
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